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Isocyanate de méthyle

Fiche toxicologique n° 162

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Édition : 2014

Bibliographie

  1. Methyl isocyanate. In : HSDB. NLM, 2012 (www.toxnet.nlm.nlh.gov).
  2. Isocyanate de méthyle. Fiche IPCS. ICSC 0004, 2003 (www.cdc.gov/niosh/ipcs/icstart.html).
  3. Methyl isocyanate. In : Gestis-databank on hazardous substances. BGIA, 2013 (www.dguv.de/ifa/gestis-database/index.jsp).
  4. Isocyanate de méthyle. In : CSST, 2012 (www.reptox.csst.qc.ca).
  5. Recommendation from the Scientific Committee on Occupational Exposure Limits for methyl isocyanate. SCOEL/SUM/118. 2006.
  6. Documentation of the TLV's and BEI's with other world wide occupational exposure values. ACGIH. 2005.
  7. Ferguson JS, Kennedy AL, Stock MF, Brown WE et al. - Uptake and distri­bution of 14C during and following exposure to 14C]methyl isocyanate. Toxicol Appl Pharmacol. 1988 ; 94(1) : 104-117.
  8. Ramachandran P, Gandhe B, Venkateswaran K, Kaushik M et al. - Gas chromatographic studies of the carbamylation of haemoglobin by methylisocyanate in rats and rabbits. J Chromat. 1988 ; 426 : 239-247.
  9. Varma DR, Guest I, Smith S et Mulay S - Dissociation between maternal en fetal toxicity of methyl isocyanate in mice and rats. J Toxicol Environ Health. 1990 ; 30(1) : 1-14.
  10. Chronic toxicity summary of methyl isocyanate. Determination of noncancer chronic reference exposure levels. OEHHA. 2001.
  11. Stevens M, Fitzgerald S, Menache M, Costa D et al. - Functional evidence of persistent airway obstruction in rats following a two-hour inhalation exposure to methyl isocyanate. Environ Health Perspect. 1987 ; 72 : 89-94.
  12. Fowler EH et Dodd DE - Respiratory tract changes in guinea pigs, rats and mice following a single six-hour exposure to methyl isocyanate vapor. Environ Health Perspect. 1987 ; 72 : 109-116.
  13. Bucher J et Uraih L - Carcinogenicity and pulmonary pathology associated with a single 2-hour inhalation exposure of laboratory rodents to methyl isocyanate. J Natl Cancer Inst. 1989 ; 81 : 1586-1587.
  14. Uraih LC, Talley FA, Mitsumori K, Gupta BN et al. - Ultrastructural changes in the nasal mucosa of Fischer 344 rats and B6C3F1 mice following an acute exposure to methyl isocyanate. Environ Health Perspect. 1987 ; 72 : 77-88.
  15. Dodd DE et Fowler EH - Methyl isocyanate subchronic vapor inhalation studies with Fischer 344 rats. Fundam Appl Toxicol. 1986 ; 7 : 502-522.
  16. Smyth H J, Carpenter CP, Weil CS, Pozzani UC et al. - Range finding toxicity data: List VII. Am Ind Hyg Assoc J. 1969 ; 30 : 470-476.
  17. Vernot EH, MacEwen JD, Haun CC et Kinkead ER - Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol. 1977 ; 42 : 417-423.
  18. Jeevaratnam K, Vijayaraghavan R, Kaushik MP et Vaidyanathan CS - Acute toxicity od methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia and hypothermia in rats. Arch Environ Contam Toxicol. 1990 ; 19 : 314-318.
  19. Jeevaratnam K et Sriramachari S - Comparative toxicity of methyl isocyanate and its hydrolytic derivatives in rats. I. Pulmonary histopathology in the acute phase. Arch Toxicol. 1994 ; 69 : 39-44.
  20. Jeevaratnam K, Bhattacharya R, Sugendran K et Vaidyanathan CS - Acute toxicity of methyl isocyanate in mammals. IV. Biochemical and hematological changes in rabbits. Biomed Environ Sci. 1991 ; 4(4) : 384-391.
  21. Ferguson J, Schaper M, Stock M, Weyel D et al. - Sensory and pulmonary irritation with exposure to methyl isocyanate. Toxicol Appl Pharmacol.1986 ; 82 : 329-335.
  22. James J, Buettner L et Hsu S - Sensory irritation of methyl isocyanate vapor. J Appl Toxicol. 1987 ; 7 : 147-148.
  23. Salmon AG, Muir MK et Andersson N - Acute toxicity of methyl isocyanate: a preliminary study of the dose response for eye and other effects. Br J Ind Med. 1985 ; 42 : 795-798.
  24. Mishra PK, Samarth RM, Pathak N et al. - Bhopal gas tragedy: Review of clinical and experimental findings after 25 years. Int J Occup Med Environ Health. 2009 ; 22(8) : 192-202.
  25. Ferguson JS et Alarie Y - Long term pulmonary impairment following a single exposure to methyl isocyanate. Toxicol Appl Pharmacol. 1991 ; 107(2) : 253-268.
  26. Mason JM, Zeiger E, Haworth J et al. - Genotoxicity studies of methyl isocyanates in salmonella, drosophila and cultured Chinese hamster ovary cells. Environ Mutagen. 1987 ; 9(1) : 19-28.
  27. Shelby M, Allen J, Caspary W, Haworth S et al. - Results of in vitro and in vivo genetic toxicity tests on methyl isocyanate. Environ Health Perspect. 1987 ; 72 : 183-187.
  28. McConnell E, Bucher J, Schwetz B, Gupta B et al. - Toxicity of methyl isocyanate. Environ Sci Technol. 1987 ; 21 : 188-193.
  29. Mishra PK, Gorantla VR, Akhtar N et al. - Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells. Environ Mol Mutagen. 2009 ; 50 : 328-336.
  30. Panwar H, Raghuram GV, Jain D et al. - Cell cycle deregulation by methyl isocyanate : implications in liver carcinogenisis. Environ Toxicol. 2012.
  31. Kar RN, Khan KA et Sethi N - Genotoxicity studies on mice after short term inhalation exposure to methyl isocyanate. Cytobios. 1989 ; 59(238-239) : 167-176.
  32. Meshram GP et Rao KM - Mutagenicity of methyl isocyanate in the modi­fied test conditions of Ames Salmonella/microsome liquid-preincubation procedure. Mutat Res. 1988 ; 204(2) : 123-129.
  33. Senthikumar CS, Sah NK et Ganesh N - Methyl isocyanate and carcinoge­nisis : Bridgeable gaps in scientific knowledge. Asian Pacific J Cancer Prev. 2012 ; 13 : 2429-2435.
  34. Bose M, Vachhrajani KD, Jha BS et Dutta KK - Methyl isocyanate induced morphological changes in the seminiferous epithelium of rats maintained on normal or protein deficient diets. Bull Environ Contam Toxicol. 1994 ; 52 : 656-661.
  35. Schwetz BA, Adkins B Jr, Harris M et al. - Methyl isocyanate: reproductive and developmental toxicology studies in mice. Environ Health Perspect. 1987 ; 72 : 149-152.
  36. Varma DR - Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy. Environ Health Perspect. 1987 ; 72 : 153-157.
  37. Singh RK, Srivastava A, Sethi N et Dayal R - Teratological studies on methylisocyanate in Charles Fosters rats. Biol Mem. 1996 ; 22(1) : 21-25.
  38. Methyl isocyanate. Update 2001. In: Documentation of the threshold limit values and biological exposures indices. Cincinnati : ACGIH ; 2011 : CD-ROM.
  39. Methyl isocyanate. Acute Exposure Guideline Levels (AEGLs). 2003 (www.epa.gov/oppt/aegl/pubs/chemlist.htm).
  40. Scientific basis for Swedish occupational standards XXIII. Consensus report for methyl isocyanate (MIC) and isocyanic acid (ICA). In : Arbete och halsa. Vetenskaplig skriftserie. National institute for working life, 2002 (gupea.ub.gu.se//handle/2077/3194?locale=en).
  41. Kimmerle G et Eben A - Zur toxicitat von methylisocyanat und dessen quantitativer bestimmung in der luft. Archiv. für Toxikologie, RFA. 1964 ; 20(4) : 235-41.
  42. Rye WA - Human responses to isocyanate exposure. J Occup Med. 1973 ; 15(3) : 306-7.
  43. Methyl isocyanate. In : Morton Grant W - Toxicology of the eye. Third edition. Springfield : Charles C Thomas ; 1986 : 621, 1083 p.
  44. Avashia B, Battigelli MC, Morgan WKC et Reger B - Effects of prolonged low exposure to methyl isocyanate. J Occup Env Med. 1996 ; 38(6) : 625-30.
  45. Ghosh BB, Sengupta S, Roy A, Maity S et al. - Cytogenetic studies in human populations exposed to gas leak at Bhopal, India. Environ Health Perspect. 1990 ; 86 : 323-6.
  1. Goswami HK - Cytogenetic effects of methyl isocyanate exposure in Bhopal. Hum Genet. 1986 ; 74(1) : 81-4.
  2. Isocyanate de méthyle. In : DEMETER. INRS, 2010 (www.inrs.fr/accueil/produits/bdd/Base-Demeter.html).
  3. Varma DR - Pregnancy complications in Bhopal women exposed to methyl isocyanate vapor. J Environ Sci Health. 1991 ; A26(8) : 1437-47.
  4. Methyl isocyanate (MIC). Method 54. In : Sampling and Analytical Methods. OSHA, 1985 (www.osha.gov/dts/sltc/methods/index.html).
  5. Forsberg K et Mandsorf SZ - Quick selection guide to chemical protective clothing. 5th ed. Hoboken : John Wiley & Sons ; 2007 : 203 p.
  6. Isocyanate de méthyle - Aide mémoire technique « Les valeurs limites d'exposition professionnelles aux agents chimiques ». ED n° 984. INRS (www.inrs.fr).
  7. Méthyl isocyanate. In : Guide to Occupational Exposure Values. ACGIH, 2013.
  8. Méthyl isocyanate. In : List of MAK and BAT Values 2013 : Maximum Concentrations and Biological Tolerance Values at the Workplace. Report 49. Deutsche Forschungsgemeinschaft (DFG) (onlinelibrary.wiley.com/book/10.1002/9783527666034).
  9. Cuves et réservoirs - Recommandation CNAMTS R 435. Paris : INRS ; 2008 (www.inrs.fr).
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